Emavusertib( CA-4948 )

Catalog No. M23815 CAS No. 1801344-14-8

COA

Datasheet

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MSDS

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Product Name

Emavusertib
Note

Research use only, not for human use.
Brief Description

Emavusertib is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
Description

Emavusertib is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
In Vitro

——
In Vivo

Animal Model:Mice bearing OCI-LY10 tumorsDosage:25, 50, or 150 mg/kg (once daily), 12.5, 25, or 50 mg/kg (twice daily)Administration:Orally, once daily or twice daily, for 14 consecutive days Result:Induced tumor growth inhibition. Emavusertib administered as a twice-daily divided dose was equivalent to the corresponding once-daily dose with regards to antitumor activity, i.e., 12.5 mg/kg BID versus 25 mg/kg QD.
Synonyms

CA-4948
Pathway

Angiogenesis
Target

FLT
Recptor

FLT3|IRAK4
Research Area

——
Indication

——

CAS Number

1801344-14-8
Formula Weight

491.5
Molecular Formula

C24H25N7O5
Purity

>98% (HPLC)
Solubility

DMSO:27.78 mg/mL (56.52 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
SMILES

CC1=NC=CC(=C1)C2=NC(=CO2)C(=O)NC3=CC4=C(N=C3N5CC[C@H](C5)O)N=C(O4)N6CCOCC6
Chemical Name

——

1.Wiese MD, et al. Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis. Expert Opin Investig Drugs. 2020 Apr 17:1-8.

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