Elatol( NSC 341593 )

Catalog No. M15006 CAS No. 55303-97-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Elatol
Note

Research use only, not for human use.
Brief Description

Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.
Description

Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types; binds in a 2:1 ratio to eIF4A1 (Kd=1.98 uM) and disrupts helicase activity, Elatol is active against eIF4A1’s ATP hydrolysis at 16.4 uM; Elatol is less potent in vitro than the well-studied eIF4A1 inhibitor silvestrol but is tolerated in vivo at ~100X relative dosing, leading to significant activity against lymphoma xenografts.
In Vitro

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In Vivo

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Synonyms

NSC 341593
Pathway

Nuclear Receptor/Transcription Factor
Target

eIF
Recptor

eIF
Research Area

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Indication

——

CAS Number

55303-97-4
Formula Weight

333.694
Molecular Formula

C15H22BrClO
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=C(CC2(CC1)C(=C)CC(C(C2(C)C)Br)O)Cl
Chemical Name

(3S,4R,6R)-4-bromo-10-chloro-5,5,9-trimethyl-1-methylidenespiro[5.5]undec-9-en-3-ol

1. Peters TL, et al. Clin Cancer Res. 2018 May 29. pii: clincanres.3645.2017.

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