Cart
sales@molnova.com
Home - Products - Nuclear Receptor/Transcription Factor - eIF - Pateamine A

Pateamine A

CAS No. 139220-18-1

Pateamine A( Pateamine )

Catalog No. M11628 CAS No. 139220-18-1

Pateamine A (Pateamine) is a potent small molecule inhibitor of eukaryotic translation that stimulates eIF4AI/II and eIF4AIII activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 3573 Get Quote
50MG 7182 Get Quote
100MG 10350 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Pateamine A
  • Note
    Research use only, not for human use.
  • Brief Description
    Pateamine A (Pateamine) is a potent small molecule inhibitor of eukaryotic translation that stimulates eIF4AI/II and eIF4AIII activity.
  • Description
    Pateamine A (Pateamine) is a potent small molecule inhibitor of eukaryotic translation that stimulates eIF4AI/II and eIF4AIII activity, but not eIF4E, eIF2α, and elF4B; inhibits protein synthesis showing an IC50 of 5 nM in HeLa cells; prevents muscle wasting caused by IFNγ and TNFα or by C26-adenocarcinoma tumours in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Pateamine
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    eIF
  • Recptor
    eIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    139220-18-1
  • Formula Weight
    555.778
  • Molecular Formula
    C31H45N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1CC(CC(=O)OC(CC(=CC=CC(=O)OC(CC2=NC1=CS2)C=C(C)C=CC(=CCN(C)C)C)C)C)N
  • Chemical Name
    4,12-Dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraene-5,13-dione, 15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethyl-1,3,5-heptatrienyl]-9,11,17-trimethyl-, (3S,6Z,8E,11S,15R,17S)- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bordeleau ME, et al. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10460-5. 2. Di Marco S, et al. Nat Commun. 2012 Jun 12;3:896. 3. Popa A, et al. BMC Genomics. 2016 Jan 14;17:52.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • eIF4A3-IN-1q

    A potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM.

  • 4E2RCat

    A small molecule inhibitor of eIF4E-eIF4G interaction with IC50 of 13.5 uM in TR-FRET-based assay.

  • Elatol

    Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.

Sign In Join Free