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Droloxifene

CAS No. 82413-20-5

Droloxifene( 3-Hydroxytamoxifen | FK-435 )

Catalog No. M16060 CAS No. 82413-20-5

A nonsteroidal selective estrogen receptor modulator (SERM) that shows 10- to 60-fold increased affinity for the estrogen receptor compared with Tamoxifen.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 177 Get Quote
10MG 267 Get Quote
25MG 464 Get Quote
50MG 662 Get Quote
100MG 888 Get Quote
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Biological Information

  • Product Name
    Droloxifene
  • Note
    Research use only, not for human use.
  • Brief Description
    A nonsteroidal selective estrogen receptor modulator (SERM) that shows 10- to 60-fold increased affinity for the estrogen receptor compared with Tamoxifen.
  • Description
    A nonsteroidal selective estrogen receptor modulator (SERM) that shows 10- to 60-fold increased affinity for the estrogen receptor compared with Tamoxifen; has reduced partial estrogen agonistic activity.Breast Cancer Phase 2 Clinical.
  • In Vitro
    Droloxifene (10 nM; 16-18 hours) induces apoptosis in MCF-7 cells. Cell Viability Assay Cell Line:MCF-7 cells Concentration:10 nM Incubation Time:16-18 hours Result:Induced cells apoptosis
  • In Vivo
    Droloxifene (5-20 mg/kg; p.o.; daily for 4 weeks) increases BMD of DFM at 10mg/kg, and completely prevents the decrease of BMC and BMD of DFM induced by ovariectomized (OVX) at 20 mg/kg/day. Animal Model:5-month-old sham-operate ratsDosage:5, 10, 20 mg/kg Administration:Oral; daily for 4 weeks Result:BMD of DFM increased significantly at 10mg/kg; completely prevented the decrease of BMC and BMD of DFM induced by OVX at 20 mg/kg/day.
  • Synonyms
    3-Hydroxytamoxifen | FK-435
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Estrogen Receptor/ERR
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    82413-20-5
  • Formula Weight
    387.52
  • Molecular Formula
    C26H29NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (129.03 mM)
  • SMILES
    CCC(=C(C1=CC=C(C=C1)OCCN(C)C)C2=CC(=CC=C2)O)C3=CC=CC=C3
  • Chemical Name
    (Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rauschning W, et al. Breast Cancer Res Treat. 1994;31(1):83-94. 2. Hasmann M, et al. Cancer Lett. 1994 Sep 15;84(2):101-16. 3. Leng Y, et al. Eur J Pharmacol. 2000 Dec 8;409(2):123-31.
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