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GLL 398

CAS No. 2077980-80-2

GLL 398( —— )

Catalog No. M29017 CAS No. 2077980-80-2

GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.

Purity : >98% (HPLC)

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25MG	1060	Get Quote
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Biological Information

Product Name

GLL 398
Note

Research use only, not for human use.
Brief Description

GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.
Description

GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.(In Vitro):GLL398 exhibits a strong dose-dependent binding profile for the estrogen receptor with a Y537S point mutation with an IC50 of 29.5 nM.
In Vitro

GLL398 is a boron-modified GW5638 analog.
In Vivo

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Synonyms

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Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

Estrogen Receptor/ERR
Research Area

——
Indication

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Chemical Information

CAS Number

2077980-80-2
Formula Weight

398.26
Molecular Formula

C25H23BO4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (627.73 mM)
SMILES

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Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

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