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Dofetilide
CAS No. 115256-11-6
Dofetilide( Tikosyn | UK 68789 )
Catalog No. M10538 CAS No. 115256-11-6
Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 45 | In Stock |
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| 10MG | 57 | In Stock |
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| 25MG | 107 | In Stock |
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| 50MG | 168 | In Stock |
|
| 100MG | 237 | In Stock |
|
| 200MG | 455 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDofetilide
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NoteResearch use only, not for human use.
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Brief DescriptionDofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug
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DescriptionDofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.(In Vitro):Dofetilide (3~100 μg/kg; i.v.) increases repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged.Dofetilide is metabolized by CYP3A4 to a mixture of inactive polar metabolites that are then excreted by the kidney.
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In Vitro——
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In VivoAnimal Model:Adult beagle dogs (13-15 kg) Dosage:3~100 μg/kg Administration:I.v.Result:Increased repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged.
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SynonymsTikosyn | UK 68789
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number115256-11-6
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Formula Weight441.56
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Molecular FormulaC19H27N3O5S2
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Purity>98% (HPLC)
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SolubilityDMSO:88 mg/mL warmed (199.29 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
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SMILESCS(=O)(NC1=CC=C(OCCN(CCC2=CC=C(NS(=O)(C)=O)C=C2)C)C=C1)=O
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Chemical NameN-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kiehn J, et al. Circulation, 1996, 94(10), 2572-2579.
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