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Dofequidar
CAS No. 129716-58-1
Dofequidar( MS-209 )
Catalog No. M11198 CAS No. 129716-58-1
A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameDofequidar
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NoteResearch use only, not for human use.
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Brief DescriptionA novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
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DescriptionA novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR; completely reverses resistance against vincristine in vitro in multidrug-resistant variants of mouse leukemia P388 cells and human leukemia K562 cells at 1-10 uM; greatly reduces the SP-derived tumor growth in vivo combined with CPT-11.Breast cancer Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsMS-209
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PathwayMembrane Transporter/Ion Channel
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TargetP-glycoprotein
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RecptorP-glycoprotein
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number129716-58-1
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Formula Weight481.5854
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Molecular FormulaC30H31N3O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5
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Chemical NameEthanone, 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nakanishi O, et al. Oncol Res. 1997;9(2):61-9.
2. Sato W, et al. Cancer Chemother Pharmacol. 1995;35(4):271-7.
3. Katayama R, et al. Cancer Sci. 2009 Nov;100(11):2060-8.
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