Disarib( —— )

Catalog No. M13120 CAS No. 1998149-15-7

Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Disarib
Note

Research use only, not for human use.
Brief Description

Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain.
Description

Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain, demonstrates strong affinity to BCL2, but not to other antiapoptotic BCL2 family members(BCL-xL, BCL2A1 etc.); is a novel BCL2 inhibitor with a unique mechanism of BCL2 inhibition.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

Chemical Information

CAS Number

1998149-15-7
Formula Weight

547.855
Molecular Formula

C26H16BrClN4OS
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

3-((2-(4-chlorobenzyl)-6-(4-bromophenyl)imidazo[2,1-b][1,3,4] -thiadiazol-5-yl)methylidene)-1,3-dihydro-2H-indol-2-one

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Iyer D, et al. FEBS J. 2016 Sep;283(18):3408-37. 2. Vartak SV, et al. Biochem Pharmacol. 2016 Dec 15;122:10-22. 3. Vartak SV, et al. Biochem Pharmacol. 2017 May 1;131:16-28. doi:

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