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TCPOBOP

CAS No. 76150-91-9

TCPOBOP( —— )

Catalog No. M24766 CAS No. 76150-91-9

TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 65 In Stock
25MG 120 In Stock
50MG 193 In Stock
100MG 305 In Stock
200MG 458 In Stock
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Biological Information

  • Product Name
    TCPOBOP
  • Note
    Research use only, not for human use.
  • Brief Description
    TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly.
  • Description
    TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCPOBOP decreases Fas-induced murine liver injury by altering Bcl-2 proteins.
  • In Vitro
    ——
  • In Vivo
    TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours. Animal Model:METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO Dosage:3 mg/kg.Administration:Oral; 1, 2, 5 days Result:Increased Liver weight to body weight.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    76150-91-9
  • Formula Weight
    402.06
  • Molecular Formula
    C16H8Cl4N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:25 mg/mL?(62.18 mM;?ultrasonic and warming and heat to 50°C)
  • SMILES
    ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718.
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