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Desidustat

CAS No. 1616690-16-4

Desidustat( —— )

Catalog No. M19960 CAS No. 1616690-16-4

Desidustat is an inhibitor of HIF hydroxylase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Desidustat
  • Note
    Research use only, not for human use.
  • Brief Description
    Desidustat is an inhibitor of HIF hydroxylase.
  • Description
    Desidustat is an inhibitor of HIF hydroxylase.(In Vivo):Desidustat (oral; 10-100 mg/kg) has good efficacy in vivo.
  • In Vitro
    ——
  • In Vivo
    Desidustat (oral; 10-100 mg/kg) has good efficacy in vivo. Animal Model:C57 Mice Dosage:10, 30, 50, 100 mg/kg; 20 mg /kg Administration:oral gavage;oral, once, daily, for 7 days.Result:Significant increased the level of EPO and Hb.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    HIF/HIF Prolyl-hydroxylase
  • Recptor
    HIF hydroxylase
  • Research Area
    Cardiovascular Disease
  • Indication
    Anaemia

Chemical Information

  • CAS Number
    1616690-16-4
  • Formula Weight
    332.31
  • Molecular Formula
    C16H16N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 30 mg/mL
  • SMILES
    OC(=O)CNC(=O)c1c(O)c2ccccc2n(OCC2CC2)c1=O
  • Chemical Name
    N-[1-(cyclopropylmethoxy)-4-hydroxy-2-oxo- 12-dihydroquinoline-3-carbonyl]glycine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jain M et al. Pharmacological inhibition of prolyl hydroxylase protects against inflammation-induced anemia via efficient erythropoiesis and hepcidin downregulation. Eur J Pharmacol. 2019 Jan 15;843:113-120.
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