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Debio-0123
CAS No. 2243882-74-6
Debio-0123( —— )
Catalog No. M37689 CAS No. 2243882-74-6
Debio-0123 (WEE1-IN-5) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 256 | In Stock |
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| 5MG | 227 | In Stock |
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| 10MG | 313 | In Stock |
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| 25MG | 537 | In Stock |
|
| 50MG | 728 | In Stock |
|
| 100MG | 995 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDebio-0123
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NoteResearch use only, not for human use.
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Brief DescriptionDebio-0123 (WEE1-IN-5) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range.
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DescriptionWEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agentsin cancer cells. WEE1-IN-5 can be used for researching anticancer.
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In VitroWEE1-IN-5 exhibits an EC50 of 188 nM in pCDC2 and an IC50 shift for CYP3A4/5.
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In VivoWEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUCint 1324 h·ng/mL and bioavailability of 35% in SD rats.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetWee1
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RecptorWee1
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Research Area——
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Indication——
Chemical Information
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CAS Number2243882-74-6
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Formula Weight511.45
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Molecular FormulaC26H28Cl2N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (39.10 mM; Ultrasonic (<60°C); )
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SMILESCN1CCC(CC1)c1ccc(Nc2ncc3C(=O)N(CN(C)c3n2)c2c(Cl)cccc2Cl)cc1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. H. Gelderblom, et al. 601TiP First-in-human phase I study of a novel oral Wee1 inhibitor (Debio 0123) in combination with carboplatin in patients with advanced solid tumours. Ann Oncol. 2020 Sep; 31: S501-S502.
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