JUN76288( WEE1-IN-3 )

Catalog No. M24035 CAS No. 2272976-28-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

JUN76288
Note

Research use only, not for human use.
Brief Description

JUN76288 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
Description

JUN76288 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
In Vitro

WEE1-IN-3 (example 1) inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively.WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?ΝΑ repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types.
In Vivo

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Synonyms

WEE1-IN-3
Pathway

Cell Cycle/DNA Damage
Target

Wee1
Recptor

Wee1
Research Area

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Indication

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CAS Number

2272976-28-8
Formula Weight

497.6
Molecular Formula

C28H31N7O2
Purity

>98% (HPLC)
Solubility

DMSO:250 mg/mL?(502.42 mM;?Need ultrasonic)
SMILES

CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC5=C(C=C4)C6(CC6)CN(C5)C)O
Chemical Name

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1.Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1.

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