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Danirixin
CAS No. 954126-98-8
Danirixin( GSK-1325756 )
Catalog No. M16816 CAS No. 954126-98-8
Danirixin (GSK-1325756) is a high-affinity, selective and reversible CXCR2 antagonist (IC50=12.5 nM, CXCL8).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 222 | In Stock |
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| 10MG | 313 | In Stock |
|
| 25MG | 529 | In Stock |
|
| 50MG | 754 | In Stock |
|
| 100MG | 1044 | In Stock |
|
| 500MG | 2088 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDanirixin
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NoteResearch use only, not for human use.
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Brief DescriptionDanirixin (GSK-1325756) is a high-affinity, selective and reversible CXCR2 antagonist (IC50=12.5 nM, CXCL8).
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DescriptionDanirixin (GSK-1325756) is a high-affinity, selective and reversible CXCR2 antagonist (IC50=12.5 nM, CXCL8); blocks the CD11b upregulation with pIC50 of 6.05 and 6.3, respectively, in rat and human whole-blood studies; blocks the influx of neutrophils into the lung in vivo in rats following aerosol lipopolysaccharide (ED50=1.4 mg/kg); orally active.COPD Phase 2 Clinical(In Vitro):Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine.
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In VitroDanirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine.
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In Vivo——
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SynonymsGSK-1325756
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorCXCL8-CXCR2
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Research AreaInflammation/Immunology
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IndicationCOPD
Chemical Information
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CAS Number954126-98-8
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Formula Weight441.9041
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Molecular FormulaC19H21ClFN3O4S
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Purity>98% (HPLC)
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SolubilityDMSO: 8 mg/mL
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SMILESClC(C(S([C@H]1CCCNC1)(=O)=O)=C2O)=CC=C2NC(NC3=CC=CC(F)=C3C)=O
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Chemical NameUrea, N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bloomer JC, et al. Eur J Pharm Biopharm. 2017 Apr 3. pii: S0939-6411(16)31009-8.
2. Miller BE, et al. BMC Pharmacol Toxicol. 2015 Jun 20;16:18.
3. Busch-Petersen J, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):338-346.
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