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α-NETA
CAS No. 31059-54-8
α-NETA( α-NETA | α NETA | αNETA | alpha NETA )
Catalog No. M13994 CAS No. 31059-54-8
A small molecule CMKLR1 antagonist that inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 (EC50=9.7 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Nameα-NETA
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule CMKLR1 antagonist that inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 (EC50=9.7 nM).
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DescriptionA small molecule CMKLR1 antagonist that inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 (EC50=9.7 nM); inhibits chemerin-triggered CMKLR1+ cell migration, suppresses CNS autoimmune inflammatory disease in vivo; also inhibits choline acetyltransferase with IC50 of 9 uM.
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In Vitroβ-NETA exhibits no effects at muscarinic receptors, ganglionic nicotinic receptors, skeletal muscular nicotinic receptors, cholinesterases or carnitine acetyltransferase at concentrations which inhibits ChA. At concentrations higher than the IC50 value to inhibit ChA, β-NETA antagonizes the effect of acetylcholine (ED50=100 μM), histamine and KCl-induced contractions in the guinea pig longitudinal ileal muscle.
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In Vivo——
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Synonymsα-NETA | α NETA | αNETA | alpha NETA
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number31059-54-8
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Formula Weight369.2
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Molecular FormulaC16H20NO ? I
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 31.25 mg/mL (84.63 mM)
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SMILESC[N+](C)(CCC(C1=CC=C2C=CC=CC2=C1)=O)C.[I-]
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Chemical NameN,N,N-trimethyl-γ-oxo-2-naphthalenepropanaminium, monoiodide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Graham KL, et al. PLoS One. 2014 Dec 1;9(12):e112925.
2. Tümmler C, et al. Oncotarget. 2017 Jul 27;8(56):95135-95151.
3. Sastry BV, et al. J Pharmacol Exp Ther. 1988 Apr;245(1):72-80.
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