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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - DS-1001b

DS-1001b

CAS No. 1898207-64-1

DS-1001b( —— )

Catalog No. M21053 CAS No. 1898207-64-1

DS-1001b is an ?inhibitor of ?mutant IDH-1 (Isocitrate Dehydrogenase-1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DS-1001b
  • Note
    Research use only, not for human use.
  • Brief Description
    DS-1001b is an ?inhibitor of ?mutant IDH-1 (Isocitrate Dehydrogenase-1).
  • Description
    DS-1001b is an ?inhibitor of ?mutant IDH-1 (Isocitrate Dehydrogenase-1).
  • In Vitro
    Cell Proliferation Assay Cell Line:JJ012, L835 Concentration:0.1, 1, 10 μM Incubation Time:14 days Result:Inhibited cell proliferation in a dose-dependent manner. GI50 values for JJ012, L835 are 81 and 77 nM.RT-PCR Cell Line:L835 Concentration:10 μM Incubation Time:6 weeks Result:Upregulated the expression of SOX9, RUNX2, COL2A1, COL10A1 and ACAN.Cell Cycle Analysis Cell Line:JJ012 Concentration:1 μM Incubation Time:7 days Result:Induced G1 phase arrest. Increased the percentage of cells in the G0/G1 phase by 5.4% and decreased that of cells in the S phase by 4.4%.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    IDH1
  • Research Area
    Cancer
  • Indication
    Glioma

Chemical Information

  • CAS Number
    1898207-64-1
  • Formula Weight
    608.92
  • Molecular Formula
    C29H29Cl3FN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:14 mg/mL (22.99 mM)
  • SMILES
    CC(C)(C)N.Cc1cn(C(=O)c2c(-c3c(Cl)cc(Cl)cc3Cl)noc2C(C)(C)F)c2cccc(/C=C/C(=O)O)c12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yoshiki A Yohei M Toshihiko W et al. ACT-14 A FIRST-IN-HUMAN STUDY OF MUTANT IDH1 INHIBITOR DS-1001B IN PATIENTS WITH RECURRENT GLIOMAS[J]. Neuro Oncology Advances(Supplement_2):Supplement_2.
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