DPA-714( —— )

Catalog No. M25016 CAS No. 958233-07-3

DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

DPA-714
Note

Research use only, not for human use.
Brief Description

DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM).
Description

DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM). It is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. [18F]DPA-714 successfully assesses for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
In Vitro

——
In Vivo

[18F]DPA-714 binding significantly increases in vivo as a result of AD‐like pathology and age in APPswe×PS1Δe9 mice.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

TSPO
Research Area

——
Indication

——

Chemical Information

CAS Number

958233-07-3
Formula Weight

398.47
Molecular Formula

C22H27FN4O2
Purity

>98% (HPLC)
Solubility

DMSO:41.67 mg/mL (104.57 mM; Need ultrasonic)
SMILES

CCN(CC)C(Cc1c2nc(C)cc(C)n2nc1-c(cc1)ccc1OCCF)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49(5):814-22.

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