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DHODH-IN-11
CAS No. 1263303-95-2
DHODH-IN-11( —— )
Catalog No. M22430 CAS No. 1263303-95-2
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 147 | Get Quote |
|
| 25MG | 279 | Get Quote |
|
| 50MG | 417 | Get Quote |
|
| 100MG | 611 | Get Quote |
|
| 500MG | 1287 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameDHODH-IN-11
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NoteResearch use only, not for human use.
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Brief DescriptionDHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a).
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DescriptionDHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure.
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In VitroDesigned a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorDHODH
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Research Area——
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Indication——
Chemical Information
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CAS Number1263303-95-2
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Formula Weight265.27
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Molecular FormulaC15H11N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (471.22 mM)
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SMILESO\N=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.
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