CX4152( CX 4152 | CX-4152 )

Catalog No. M14121 CAS No. 333351-27-2

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HNMR

HPLC

MSDS

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Product Name

CX4152
Note

Research use only, not for human use.
Brief Description

A novel potent, selective CXCR2 inhibitor with IC50 of 7.6 nM.
Description

A novel potent, selective CXCR2 inhibitor with IC50 of 7.6 nM; displays>1,000-fold selectivity over CXCR4 (IC50>50 uM); inhibits CXCR2 signaling through downregulation of surface CXCR2; significantly inhibits CXCL8-mediated neutrophil migration and LPS-induced lung inflammation in mice; inhibits CXCR2/β-arrestin-2 association, cell migration and proliferation, and acute inflammation in mouse models.
In Vitro

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In Vivo

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Synonyms

CX 4152 | CX-4152
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

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Indication

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CAS Number

333351-27-2
Formula Weight

435.538
Molecular Formula

C25H25NO4S
Purity

>98% (HPLC)
Solubility

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SMILES

CC1=C(C2=C(O1)C3=CC=CC=C3C(=C2)NS(=O)(=O)C4=CC=C(C=C4)C(C)(C)C)C(=O)C
Chemical Name

N-(3-acetyl-2-methylnaphtho[1,2-b]furan-5-yl)-4-(tert-butyl)benzenesulfonamide

1. Ha H, et al. J Chem Inf Model. 2015 Aug 24;55(8):1720-38.

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