CX-157( —— )

Catalog No. M33327 CAS No. 205187-53-7

CX-157 (KP 157) is a novel monoamine oxidase-A (MAO-A) inhibitor for the study of depression-like neurological disorders and cancer.

Purity : >98% (HPLC)

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Biological Information

Product Name

CX-157
Note

Research use only, not for human use.
Brief Description

CX-157 (KP 157) is a novel monoamine oxidase-A (MAO-A) inhibitor for the study of depression-like neurological disorders and cancer.
Description

CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL.
In Vitro

——
In Vivo

CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3?ng/mL. CX-157 is an investigational compound currently in development for the treatment of major depressive disorder (MDD). Mechanistic studies in animals have shown that CX-157 acts to inhibit MAO-A activity in a reversible and competitive manner, elevating brain levels of monoamine neurotransmitters.
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

MAO
Recptor

MAO
Research Area

——
Indication

——

Chemical Information

CAS Number

205187-53-7
Formula Weight

348.27
Molecular Formula

C14H8F4O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S1(=O)C2=CC=C(F)C=C2OC3=CC(OCC(F)(F)F)=CC=C31
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Fowler JS, et al. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31.?

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