CRK12-IN-2

Research use only, not for human use.

CRK12-IN-2 is a potent inhibitor of CRK12.CRK12-IN-2 inhibits the parasite, with EC50 values of 3.2 and 0.08 nM for Trypanosoma congolense and Trypanosoma vivax, respectively.

CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis.

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CRK12-IN-2 (10 mg/kg; s.c. once daily for 4 days) effectively cures mice with T. congolense- and T. vivax-infection.Animal Model:Mice with T. congolense and T. vivax infection Dosage:10 mg/kg Administration: Subcutaneous injection; 10 mg/kg once daily; for 4 days Result:Fully cured both T. congolense- and T. vivax-infected mice for 4 days at a dose of 10 mg/kg.

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Microbiology/Virology

Parasite

Parasite

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1990479-17-8

529.67

C23H33F2N5O3S2

>98% (HPLC)

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C(=O)(C=1SC(N[C@@H]2CC[C@@H](NS(CC(C)C)(=O)=O)CC2)=NC1N)C3=C(F)C=C(CN(C)C)C=C3F

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(-20℃)

With Ice Pack

≥ 2 years