Closantel( NSC 335306 )

Catalog No. M15114 CAS No. 57808-65-8

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HNMR

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Product Name

Closantel
Note

Research use only, not for human use.
Brief Description

A veterinary anthelmintic with known proton ionophore activities; is identified as a potent and specific inhibitor of filarial chitinases.
Description

A veterinary anthelmintic with known proton ionophore activities; is identified as a potent and specific inhibitor of filarial chitinases; also shows to be an allosteric inhibitor of SPAK and OSR1.Parasite Infection Approved(In Vitro):Closantel, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase.
In Vitro

Closantel, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase.
In Vivo

——
Synonyms

NSC 335306
Pathway

Microbiology/Virology
Target

Parasite
Recptor

Antiparasitic
Research Area

Infection
Indication

Parasite Infection

CAS Number

57808-65-8
Formula Weight

663.0737
Molecular Formula

C22H14Cl2I2N2O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 49 mg/mL
SMILES

CC1=CC(C(C#N)C2=CC=C(Cl)C=C2)=C(Cl)C=C1NC(=O)C1=CC(I)=CC(I)=C1O
Chemical Name

Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-

1. AlAmri MA, et al. ChemMedChem. 2017 May 9;12(9):639-645. 2. Gloeckner C, et al. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3424-9.

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