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CNX-774
CAS No. 1202759-32-7
CNX-774( CNX774 | CNX 774 | CNX-774 )
Catalog No. M17187 CAS No. 1202759-32-7
CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 115 | In Stock |
|
| 25MG | 222 | In Stock |
|
| 50MG | 368 | In Stock |
|
| 100MG | 536 | In Stock |
|
| 500MG | 1161 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCNX-774
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NoteResearch use only, not for human use.
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Brief DescriptionCNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).
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DescriptionCNX-774 is a potent Btk inhibitor (IC50 < 1 nM). Recently Bruton's tyrosine kinase (BTK) , a crucial terminal kinase enzyme in the B-cell antigen receptor (BCR) signaling pathway, has emerged as an attractive target for therapeutic intervention in human malignancies and autoimmune disorders.
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In VitroCNX-774 strongly inhibits Btk activity in Ramos cells with an IC50 of 1-10 nM. CNX-774 demonstrates strong time- and dose-dependent occupancy of Btk in Ramos cells.
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In VivoCNX-774 is stable and non-reactive in fresh human and rat whole blood and does not covalently bond to any of the mid-level abundance human plasma proteins.CNX-774 demonstrates potent inhibitory activity towards the intended target, Btk, while achieving remarkable specificity in a variety of assays designed to assess off-target reactivity towards abundant cellular thiols and blood proteins.
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SynonymsCNX774 | CNX 774 | CNX-774
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PathwayApoptosis
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TargetApoptosis
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RecptorBTK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1202759-32-7
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Formula Weight499.5
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Molecular FormulaC26H22FN7O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 45 mg/mL. 90.09 mM
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SMILESc1c(ccc(c1)Oc1ccnc(c1)C(=O)NC)Nc1nc(c(cn1)F)Nc1cccc(c1)NC(=O)C=C
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Chemical Name4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Labenski M. 17th North Am Meet Int Soc Study Xenobiot (ISSX) 2011. Abst. P211.
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