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CHMFL-KIT-031
CAS No. ——
CHMFL-KIT-031( —— )
Catalog No. M16977 CAS No. ——
CHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCHMFL-KIT-031
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NoteResearch use only, not for human use.
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Brief DescriptionCHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM.
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DescriptionCHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM, 10-20 fold selectivity over KIT wt; also displays 15-400-fold selectivity over other primary mutants such as L576P and secondary mutants including T670I, V654A as well as N822K and D816V; exhibits a selectivity S score (1) of 0.01 among 468 kinases/mutants in the KINOMEScan? assay; inhibits the proliferation of BaF3-TEL-KIT-V559D cells with IC50 of 25 nM, shows potent inhibitory efficacy for KIT V559D mediated signaling pathways in cell and anti-tumor activity in vivo.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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Targetc-Kit
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Recptorc-Kit
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight487.516
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Molecular FormulaC26H25N5O5
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(E)-3,4,5-trimethoxy-N-(2-oxo-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)ethyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu K, et al. Oncotarget. 2017 Nov 15;8(67):111110-111118.
molnova catalog
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