CHM-1( NSC656158 )

Catalog No. M27612 CAS No. 154554-41-3

CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.

Purity : >98% (HPLC)

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Biological Information

Product Name

CHM-1
Note

Research use only, not for human use.
Brief Description

CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
Description

CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.(In Vitro):CHM-1 (0-10 μM; 24 hours) significantly increased the binding of cyclin B1 to Cdc2 and induced change in expressed and phosphorylated status of G2-M regulators in HA22T cells. CHM-1 (0-100μM; 24 hours) induced significant concentration-dependent growth inhibition in HA22T, Hep3B, and HepG2 cells, with the most potent effects observed in HA22T cells with an IC50 of 0.75 μM).(In Vivo):In male severe combined immunodeficient mice, CHM-1 (10 mg/kg; i.p.) induced inhibition of HA22T tumor growth in a dose-dependent manner.
In Vitro

CHM-1 (0-100μM; 24 hours) induces significant concentration-dependent growth inhibition in HA22T, Hep3B, and HepG2 cells, with the most potent effects observed in HA22T cells (IC50 = 0.75 μM).CHM-1 (0-10 μM; 24 hours) significantly increases the binding of cyclin B1 to Cdc2 in HA22T cells. Cell Viability Assay Cell Line:HA22T, Hep3B, and HepG2 cells Concentration:0-100 μM Incubation Time:24 hours Result:Induced G2-M arrest of the cell cycle followed by apoptosis.Western Blot Analysis Cell Line:HA22T cells Concentration:0-10 μM Incubation Time:24 hours Result:Induced change in expressed and phosphorylated status of G2-M regulators in human hepatocellular carcinoma cells.
In Vivo

CHM-1 (10 mg/kg; I.p.) induces a dose-dependent inhibition of HA22T tumor growth. Animal Model:Male severe combined immunodeficient mice (HA22T)Dosage:10 mg/kg Administration:I.p.Result:Induced a dose-dependent inhibition of HA22T tumor growth.
Synonyms

NSC656158
Pathway

Apoptosis
Target

Apoptosis
Recptor

Antibiotic|P-glycoprotein
Research Area

——
Indication

——

Chemical Information

CAS Number

154554-41-3
Formula Weight

283.258
Molecular Formula

C16H10FNO3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 5 mg/mL (17.65 mM)
SMILES

Fc1ccccc1-c1cc(=O)c2cc3OCOc3cc2[nH]1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92.

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