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CHIR98014
CAS No. 556813-39-9
CHIR98014( CHIR98014 | CHIR-98014 | CHIR 98014 )
Catalog No. M17541 CAS No. 556813-39-9
CHIR 98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 282 | In Stock |
|
| 50MG | 462 | In Stock |
|
| 100MG | 669 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCHIR98014
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NoteResearch use only, not for human use.
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Brief DescriptionCHIR 98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
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DescriptionCHIR98014, also known as CT-98024, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
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In Vitro——
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In Vivo——
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SynonymsCHIR98014 | CHIR-98014 | CHIR 98014
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PathwayAutophagy
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TargetCXCR
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RecptorGSK-3α/β| p70 S6K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number556813-39-9
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Formula Weight486.31
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Molecular FormulaC20H17Cl2N9O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (257.04 mM)
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SMILESc1cc(c(cc1Cl)Cl)c1nc(ncc1c1[nH]ccn1)NCCNc1nc(c(cc1)[N+](=O)[O-])N
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Chemical NameN2-(2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ring DB,et al. Diabetes. 2003, 52(3), 588-595.
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