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CHBO4
CAS No. 98991-32-3
CHBO4( —— )
Catalog No. M36965 CAS No. 98991-32-3
CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and the Ki value was 0.010 ± 0.005 μM.CHBO4 reduces cellular damage by scavenging intracellular reactive oxygen species (ROS), and can be used to study Parkinson's disease (PD).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 79 | In Stock |
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| 5MG | 113 | In Stock |
|
| 10MG | 166 | In Stock |
|
| 25MG | 271 | In Stock |
|
| 50MG | 408 | In Stock |
|
| 100MG | 588 | In Stock |
|
| 500MG | 1251 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCHBO4
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NoteResearch use only, not for human use.
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Brief DescriptionCHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and the Ki value was 0.010 ± 0.005 μM.CHBO4 reduces cellular damage by scavenging intracellular reactive oxygen species (ROS), and can be used to study Parkinson's disease (PD).
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DescriptionCHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research.
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In VitroCell Cytotoxicity Assay Cell Line:Vero cells Concentration:10-500 μg/mL Incubation Time:48 hResult:Reduced cell viability percentage with the IC50 value of 128.8 μg/mLDecreased cellular density, cellular shrinkage, and blebbing exposed to concentrations (100-300 μg/mL) in Vero cells
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetMAO
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RecptorMAO | ROS
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Research Area——
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Indication——
Chemical Information
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CAS Number98991-32-3
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Formula Weight305.14
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Molecular FormulaC15H10BrFO
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Purity>98% (HPLC)
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Solubility——
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SMILESC(C=CC1=CC=C(F)C=C1)(=O)C2=CC=C(Br)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Thomas Parambi DG, et al. Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: Synthesis, biochemistry, and molecular dynamics study. Comput Biol Chem. 2023 Aug;105:107899.?
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CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and the Ki value was 0.010 ± 0.005 μM.CHBO4 reduces cellular damage by scavenging intracellular reactive oxygen species (ROS), and can be used to study Parkinson's disease (PD).
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