CCG-224406( CCG 224406 | CCG224406 )

Catalog No. M12895 CAS No. 1870843-22-3

COA

Datasheet

HNMR

HPLC

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Product Name

CCG-224406
Note

Research use only, not for human use.
Brief Description

A highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM.
Description

A highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM; displays >700-fold selectivity over other GRK subfamilies, and no detectable inhibition of ROCK1.
In Vitro

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In Vivo

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Synonyms

CCG 224406 | CCG224406
Pathway

Others
Target

GRK (GPCRK)
Recptor

GRK (GPCRK)
Research Area

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Indication

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CAS Number

1870843-22-3
Formula Weight

558.57
Molecular Formula

C29H27FN6O5
Purity

>98% (HPLC)
Solubility

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SMILES

O=C1NC(C2=CC=C(F)C(C(NCC3=C(OC)C=CC=C3OC)=O)=C2)C(C(NC4=CC5=C(C=C4)NN=C5)=O)=C(C)N1
Chemical Name

4-(3-((2,6-dimethoxybenzyl)carbamoyl)-4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

1. Waldschmidt HV, et al. J Med Chem. 2016 Apr 28;59(8):3793-807.

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