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CBP-93872
CAS No. 67427-51-4
CBP-93872( CBP93872 | CBP 93872 )
Catalog No. M15571 CAS No. 67427-51-4
A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCBP-93872
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NoteResearch use only, not for human use.
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Brief DescriptionA potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.
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DescriptionA potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint; directly suppresses the growth of p53-mutated cancer cell lines with wild-type CDKN2A by eliciting G(1) arrest, but not CDKN2A-deleted and/or wild-type p53 lines; decreases phospho-cdc2 Y15 by inhibiting phosphorylation of Chk1; specifically inhibits DSB-mediated and Nbs1-dependent activation of ATR.
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In Vitro——
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In Vivo——
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SynonymsCBP93872 | CBP 93872
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PathwayCell Cycle/DNA Damage
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TargetATM/ATR
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RecptorATM/ATR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number67427-51-4
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Formula Weight259.14
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Molecular FormulaC10H15BrN2O
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Purity>98% (HPLC)
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Solubility——
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SMILESOC(CNC1=CC=C(C)C=C1Br)CN
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Chemical Name1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Harada N, et al. Anticancer Drugs. 2011 Nov;22(10):986-94.
2. Hirokawa T, et al. Cancer Res. 2014 Jul 15;74(14):3880-9.
3. Iwata T, et al. PLoS One. 2017 May 30;12(5):e0178221.
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