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Benzolamide
CAS No. 3368-13-6
Benzolamide( CL 11366 | CL-11366 | CL11366 | W 1803 | W-1803 )
Catalog No. M27753 CAS No. 3368-13-6
Benzolamide inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | Get Quote |
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| 10MG | 72 | Get Quote |
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| 25MG | 147 | Get Quote |
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| 50MG | 222 | Get Quote |
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| 100MG | 331 | Get Quote |
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| 200MG | 489 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBenzolamide
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NoteResearch use only, not for human use.
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Brief DescriptionBenzolamide inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.
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DescriptionBenzolamide inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.(In Vitro):Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively. Benzolamide shows selectivity for CAS3 with a Ki of 54 nM over CAS1 with a Ki of 2115 nM and CAS2 with a Ki of 410 nM.(In Vivo):Administration of 90 μmol/kg Benzolamide decreases brain pH and suppresses electrographic post-asphyxia seizures in rats.
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In Vitro——
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In VivoAnimal Model:Male and female Wistar Han rats (11-day-old).Dosage:90 μmol/kg Administration:A single i.p.Result:Induced a fast brain acidosis of a comparable magnitude.Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH.
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SynonymsCL 11366 | CL-11366 | CL11366 | W 1803 | W-1803
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PathwayMembrane Transporter/Ion Channel
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TargetCarbonic Anhydrase
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number3368-13-6
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Formula Weight320.36
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Molecular FormulaC8H8N4O4S3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (780.35 mM)
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SMILESNS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Facchin G, et al. Experimental and theoretical studies of copper complexes with isomeric dipeptides as novel candidates against breast cancer. J Inorg Biochem. 2016;162:52‐61.
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