Cart
sales@molnova.com
Becampanel
CAS No. 188696-80-2
Becampanel( AMP 397 )
Catalog No. M12950 CAS No. 188696-80-2
Becampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBecampanel
-
NoteResearch use only, not for human use.
-
Brief DescriptionBecampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM.
-
DescriptionBecampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM; has anticonvulsant activity for the treatment of epilepsy, neuropathic pain and cerebral ischemia.Epilepsy Phase 2 Discontinued.
-
In VitroBecampanel is negative in a mouse lymphoma tk assay, which includes a 24 h treatment without S9. A weak micronucleus induction in vitro is found at the highest concentrations tested in V79 cells with S9.
-
In VivoBecampanel is negative in the following in vivo studies, which includes the maximum tolerated doses of 320 mg/kg in mice and 2000 mg/kg in rats. Becampanel has no genotoxic potential in vivo.
-
SynonymsAMP 397
-
PathwayMembrane Transporter/Ion Channel
-
TargetiGluR
-
RecptoriGluR
-
Research AreaNeurological Disease
-
IndicationEpilepsy
Chemical Information
-
CAS Number188696-80-2
-
Formula Weight330.191
-
Molecular FormulaC10H11N4O7P
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1C(NC2=C(C(CNCP(O)(O)=O)=CC([N+]([O-])=O)=C2)N1)=O
-
Chemical Name((((7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl)amino)methyl)phosphonic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kwan P, et al. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22.
2. Citraro R, et al. Expert Opin Ther Targets. 2014 Mar;18(3):319-34.
molnova catalog
related products
-
Tezampanel
Tezampanel (LY 293558, NGX 424) is a competitive antagonist of the AMPA and kainate receptors with selectivity for the GluR5 subtype of the kainate receptor.
-
GYKI 52466 dihydroch...
GYKI 52466 is a selective, non-competitive, orally active AMPA receptor (AMPAR) antagonist with IC50 of 10-20 uM against AMPA-induced responses.
-
Traxoprodil
A potent and NR2B-selective NMDA receptor antagonist; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM).
