BTdCPU( —— )

Catalog No. M20636 CAS No. 1257423-87-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

BTdCPU
Note

Research use only, not for human use.
Brief Description

BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator.?BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
Description

BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator.?BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
In Vitro

Western Blot Analysis Cell Line:MM1.S and MM1.R cells Concentration:10 μMIncubation Time:0, 4, 8 h Result:Induced phosphorylation of eIF2α and upregulated mRNA and protein levels of the pro-apoptotic protein CHOP.Western Blot Analysis Cell Line:Bone marrow mononuclear cells (MNC) from multiple myeloma (MM) patient or healthy donor Concentration:10 μM Incubation Time:0, 4, 8 h Result:Induced early expression of CHOP in MM patient cells, but not in healthy bone marrow mononuclear cells (MNC).
In Vivo

Animal Model:Female nude mice (mice xenograft breast tumors model).Dosage:175 mg/kg Administration:Intraperitoneal injection; single daily for 21 days Result:Led to complete tumor stasis,which persisted for the remainder of the 3-week study.Showed good safety in mice.
Synonyms

——
Pathway

Apoptosis
Target

PERK
Recptor

eIF-2α
Research Area

——
Indication

——

1.Burwick N Zhang MYet al.The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma[J].Leuk Res. 2017 Apr;55:23-32.?

Calculator

molnova catalog