BSJ-04-122

Research use only, not for human use.

BSJ-04-122 is a covalent dual inhibitor of MKK4 and MKK7, demonstrating IC50 values of 4 nM and 181 nM, respectively. [BSJ-04-122] can be used for cancer research.

BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer.

Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:1, 5, 10 μM Incubation Time:6 h Result:Significantly decreased levels of T183/Y185 pJNK at 5 μM.Cell Proliferation Assay Cell Line:MDA-MB-231 cells Concentration:1-100 μM; 0, 1.25, 2.5, 5, 10, 20 μM Incubation Time:72 h Result:Exhibited antiproliferative effects when combination with JNK-IN-8 in MDA-MB-231 cells.

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MAPK/ERK Signaling

JNK

JNK

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2513289-74-0

313.74

C15H12ClN5O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (318.74 mM; Ultrasonic )

N(C1=C2C(NC=C2Cl)=NC=N1)C3=C(NC(C=C)=O)C=CC=C3

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(-20℃)

With Ice Pack

≥ 2 years