BMS-794833( BMS794833 )

Catalog No. M10589 CAS No. 1174046-72-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BMS-794833
Note

Research use only, not for human use.
Brief Description

BMS794833?is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM.
Description

BMS794833?is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM; also inhibits Ron, Axl and Flt-3 with IC50<3 nM; shows selectivity over a panel of >200 RTKs, non-RTKs and serine/threonine kinases; inhibits the cell growth in GTL-16 gastric carcinomas with an IC50 of 39 nM; active in multiple tumor models.Solid Tumors Phase 1 Clinical.
In Vitro

BMS794833 inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with an IC50 of 39 nM.
In Vivo

BMS-794833 is active by greater than 50% tumor growth inhibition for at least one tumor doubling time in the GTL-16 gastric carcinoma model. No toxicity is observed at any of the dose levels when administered once daily for a duration of 14 days.
Synonyms

BMS794833
Pathway

Angiogenesis
Target

c-Met/HGFR
Recptor

Met|VEGFR2
Research Area

Cancer
Indication

Solid Tumors

CAS Number

1174046-72-0
Formula Weight

468.84
Molecular Formula

C23H15ClF2N4O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F
Chemical Name

3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-