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BMS-265246
CAS No. 582315-72-8
BMS-265246( BMS265246 | BMS-265246 | BMS 265246 )
Catalog No. M15136 CAS No. 582315-72-8
BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 102 | In Stock |
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| 10MG | 177 | In Stock |
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| 25MG | 350 | In Stock |
|
| 50MG | 530 | In Stock |
|
| 100MG | 759 | In Stock |
|
| 500MG | 1557 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-265246
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay.
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DescriptionBMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.
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In VitroRT-PCR Cell Line:Calu-3 cells Concentration:9 nM Incubation Time:24 hours Result:Abrogated the ability of CHI3L1 (chitinase 3-like-1) to stimulate epithelial cells ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases).
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In Vivo——
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SynonymsBMS265246 | BMS-265246 | BMS 265246
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK1/CyclinB| CDK2/CyclinE| CDK4/CyclinD
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number582315-72-8
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Formula Weight345.34
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Molecular FormulaC18H17F2N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: 20 mg/mL (57.91 mM)
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SMILESO=C(C1=CN=C(NN=C2)C2=C1OCCCC)C3=C(F)C=C(C)C=C3F
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Chemical Name(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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ON123300
ON123300 is a potent, multi-targeted kinase inhibitor with IC50 of 5, 3.9, 26, 26, 9.2 and 11 nM for ARK5, CDK4, PDGFRβ, FGFR1, RET and FYN, respectively.
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Trilaciclib hydrochl...
Trilaciclib hydrochloride is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Incubation with Trilaciclib hydrochloride (G1T28) for 24 hours can induce a strong G1 cell cycle arrest (time=0). Cells have re-entered the cell cycle and demonstrate cell-cycle kinetics similar to untreated control cells By 16 hours after Trilaciclib hydrochloride washout.
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Alsteropaullone
Alsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM.
