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BML-278
CAS No. 120533-76-8
BML-278( —— )
Catalog No. M37061 CAS No. 120533-76-8
BML-278 is a SIRT1 activator with an EC150 of 1 μM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | Get Quote |
|
| 10MG | 86 | Get Quote |
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| 25MG | 153 | Get Quote |
|
| 50MG | 229 | Get Quote |
|
| 100MG | 302 | Get Quote |
|
| 500MG | 666 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBML-278
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NoteResearch use only, not for human use.
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Brief DescriptionBML-278 is a SIRT1 activator with an EC150 of 1 μM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development.
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DescriptionBML-278 is a SIRT1 activator (EC150: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSirtuin | Histone Methyltransferase
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Research Area——
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Indication——
Chemical Information
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CAS Number120533-76-8
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Formula Weight391.46
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Molecular FormulaC24H25NO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (25.55 mM; Ultrasonic (<60°C)
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SMILESCCOC(=O)C1=CN(Cc2ccccc2)C=C(C1c1ccccc1)C(=O)OCC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Adamkova K, et al. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol. 2017 Nov 1;8:83.?
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