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BLU-263

CAS No. 2505078-08-8

BLU-263( —— )

Catalog No. M37619 CAS No. 2505078-08-8

BLU-263 is an investigational, potent, and selective oral small molecule inhibitor of KIT with sub-nanomolar potency against D816V-mutant KIT.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 91 Get Quote
5MG 141 Get Quote
10MG 226 Get Quote
25MG 420 Get Quote
50MG 550 Get Quote
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Biological Information

  • Product Name
    BLU-263
  • Note
    Research use only, not for human use.
  • Brief Description
    BLU-263 is an investigational, potent, and selective oral small molecule inhibitor of KIT with sub-nanomolar potency against D816V-mutant KIT.
  • Description
    Elenestinib (BLU-263) is a potent and orally active tyrosine kinase inhibitor. Elenestinib has the potential for the research of systemic mastocytosis (SM). Elenestinib inhibits KIT D816V with an IC50 value of 0.2 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    c-Kit
  • Recptor
    c-Kit
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2505078-08-8
  • Formula Weight
    528.58
  • Molecular Formula
    C27H29FN10O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (236.48 mM; Ultrasonic )
  • SMILES
    C[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CCO)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dave N, et al. Safety and pharmacokinetics of BLU-263, a next-generation KIT inhibitor, in healthy volunteers[C]//Cancer Res (AACR Annual Meeting Abstracts). 2021, 122.
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