BAY-598( —— )

Catalog No. M20776 CAS No. 1906919-67-2

BAY-598 is a selective inhibitor of SMYD2?with IC50 values of 27 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

BAY-598
Note

Research use only, not for human use.
Brief Description

BAY-598 is a selective inhibitor of SMYD2?with IC50 values of 27 nM.
Description

BAY-598 is a selective inhibitor of SMYD2?with IC50 values of 27 nM.
In Vitro

BAY-598 treatment blocks in vitro methylation of MAPKAPK3 by SMYD2 but has no activity against the SMYD2-related KMT SMYD3. BAY-598 treatment reduces the growth of Kras;p53 mutant PDAC cells after 9 d in culture but has little impact on the growth of Kras;p53;Smyd2 mutant cells.
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

SMYD2
Research Area

——
Indication

——

Chemical Information

CAS Number

1906919-67-2
Formula Weight

525.34
Molecular Formula

C22H20Cl2F2N6O3
Purity

>98% (HPLC)
Solubility

DMSO:125 mg/mL (237.94 mM)
SMILES

CCN(C(=O)CO)C1CN(C(=Nc2cccc(OC(F)F)c2)NC#N)N=C1c1ccc(Cl)c(Cl)c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Reynoird N Mazur P K Stellfeld T et al. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer[J]. Genes & Development 2016:genesdev;gad.275529.115v1.

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