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Atiprimod
CAS No. 123018-47-3
Atiprimod( SKF 106615 | Azaspirane )
Catalog No. M10907 CAS No. 123018-47-3
Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1233 | Get Quote |
|
| 50MG | 2502 | Get Quote |
|
| 100MG | 3330 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAtiprimod
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NoteResearch use only, not for human use.
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Brief DescriptionAtiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways.
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DescriptionAtiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways; efficaciously inhibits the proliferation of FDCP-EpoR JAK2 (V617F) (IC50=0.42 uM) and SET-2 cells (IC50= 0.53 uM); blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells (MM.1S, U266, and RPMI8226 MM cell lines IC50=0.5-1.25 uM), significantly inhibits production of IL-6 and inflammation in rat arthritis and autoimmune animal models.Brain Cancer Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsSKF 106615 | Azaspirane
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK
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Research AreaCancer
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IndicationBrain Cancer
Chemical Information
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CAS Number123018-47-3
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Formula Weight336.608
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Molecular FormulaC22H44N2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCN(CC)CCCN1CCC2(CCC(CCC)(CCC)CC2)C1
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Chemical NameN,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Quintás-Cardama A, et al. Invest New Drugs. 2011 Oct;29(5):818-26.
2. Neri P, et al. Leukemia. 2007 Dec;21(12):2519-26.
3. Hamasaki M, et al. Blood. 2005 Jun 1;105(11):4470-6.
4. Choudhari SR, et al. Mol Cancer Ther. 2007 Jan;6(1):112-21.
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