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Itacitinib
CAS No. 1334298-90-6
Itacitinib( INCB-039110 )
Catalog No. M11330 CAS No. 1334298-90-6
A potent and selective JAK1 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 59 | In Stock |
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| 5MG | 102 | In Stock |
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| 10MG | 170 | In Stock |
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| 25MG | 309 | In Stock |
|
| 50MG | 515 | In Stock |
|
| 100MG | 740 | In Stock |
|
| 500MG | 1467 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameItacitinib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective JAK1 inhibitor.
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DescriptionA potent and selective JAK1 inhibitor; shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively; orally bioactive.Blood Cancer Phase 2 Clinical(In Vitro):Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis.
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In VitroItacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis.
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In Vivo——
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SynonymsINCB-039110
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK1
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1334298-90-6
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Formula Weight553.5142
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Molecular FormulaC26H23F4N9O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESN#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1
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Chemical Name3-Azetidineacetonitrile, 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang Y, et al. Drug Metab Dispos. 2015 Apr;43(4):485-9.
2. Kim MK, et al. J Med Chem. 2015 Sep 24;58(18):7596-602.
3. Norman P. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.
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