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Angstrom6

CAS No. 220334-14-5

Angstrom6( —— )

Catalog No. M34159 CAS No. 220334-14-5

Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Angstrom6
  • Note
    Research use only, not for human use.
  • Brief Description
    Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.
  • Description
    Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57Bl/6 mice (bearing B16-F10 cells)Dosage:100 mg/kg Administration:S.c.; twice a day for 11 days Result:Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    PAI-1
  • Recptor
    PAI-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    220334-14-5
  • Formula Weight
    910.97
  • Molecular Formula
    C39H62N10O15
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (109.77 mM; Ultrasonic )H2O : ≥ 100 mg/mL (109.77 mM)
  • SMILES
    CC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(N)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111(1):89-94.?
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