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Aminooxy-PEG4-alcohol

CAS No. 106492-60-8

Aminooxy-PEG4-alcohol( —— )

Catalog No. M33266 CAS No. 106492-60-8

Aminooxy-PEG4-alcohol is both a non-cleavable 4-unit PEG ADC linker and a PEG-based PROTAC linker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Aminooxy-PEG4-alcohol
  • Note
    Research use only, not for human use.
  • Brief Description
    Aminooxy-PEG4-alcohol is both a non-cleavable 4-unit PEG ADC linker and a PEG-based PROTAC linker.
  • Description
    Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
  • In Vitro
    ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADCs Linker/Click Chemistry
  • Recptor
    ADC Linker | PROTAC Linker
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    106492-60-8
  • Formula Weight
    209.24
  • Molecular Formula
    C8H19NO5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(OCCOCCO)COCCON
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Heather D. Maynard, et al. Method of creating hydrogels through oxime bond formation. US20150202305A1.
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