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Aligeron

CAS No. 70713-45-0

Aligeron( —— )

Catalog No. M34866 CAS No. 70713-45-0

Aligeron, a non-selective prostaglandin (PG) antagonist, inhibits PGF2α- and PGE2-induced blood pressure decreases in cats and can prevent PGF2α-induced diarrhea in mice and PGE2-induced paw edema in rats.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Aligeron
  • Note
    Research use only, not for human use.
  • Brief Description
    Aligeron, a non-selective prostaglandin (PG) antagonist, inhibits PGF2α- and PGE2-induced blood pressure decreases in cats and can prevent PGF2α-induced diarrhea in mice and PGE2-induced paw edema in rats.
  • Description
    Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
  • In Vitro
    Aligeron shows a broad spectrum of antagonistic action against different spasmogens in different isolated organs. The experiments on isolated perfused rabbit artery shows the antagonistic action of aligeron against the vasoconstrictor effects of noradrenaline and adrenaline.
  • In Vivo
    In hypoventilation hypoxia, aligeron (5 mg/kg i.v.) and cinnarizine increase cortical resistance to hypoxia and accelerated the recovery of cortical bioelectrical activity. In KCl- and AMP-induced depressions aligeron shows a protective effect manifested in a decrease of the degree and duration of the depression.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    Prostaglandin Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    70713-45-0
  • Formula Weight
    292.42
  • Molecular Formula
    C20H24N2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C=CCN1CCN(CC1)C(C=2C=CC=CC2)C=3C=CC=CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Miyares K, et al. Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli. Methods Find Exp Clin Pharmacol. 1985 Sep;7(9):473-6.?
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