Cart
sales@molnova.com
AZD-1480
CAS No. 935666-88-9
AZD-1480( AZD1480 | AZD 1480 )
Catalog No. M16692 CAS No. 935666-88-9
A potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 47 | In Stock |
|
| 10MG | 73 | In Stock |
|
| 25MG | 129 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAZD-1480
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.
-
DescriptionA potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM; demonstrates significant JAK2 selectivity over JAK3 and marginal selectivity over JAK1; blocks STAT3 phosphorylation in a panel of human solid tumor cell lines, potently inhibits the growth of the TEL-Jak2 cell line (GI50=60 nM); suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity.Liver Cancer Phase 1 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsAZD1480 | AZD 1480
-
PathwayAngiogenesis
-
TargetJAK
-
RecptorJAK2
-
Research AreaCancer
-
IndicationLiver Cancer
Chemical Information
-
CAS Number935666-88-9
-
Formula Weight348.766
-
Molecular FormulaC14H14ClFN8
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESCC1=CC(NC2=NC(N[C@H](C3=NC=C(F)C=N3)C)=NC=C2Cl)=NN1
-
Chemical Name2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hedvat M, et al. Cancer Cell. 2009 Dec 8;16(6):487-97.
2. Ioannidis S, et al. J Med Chem. 2011 Jan 13;54(1):262-76.
3. Scuto A, et al. Leukemia. 2011 Mar;25(3):538-50.
4. Xin H, et al. Cancer Res. 2011 Nov 1;71(21):6601-10.
molnova catalog
related products
-
AZD-1480
A potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.
-
ZM39923 hydrochlorid...
ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1.
-
JAK-IN-35
JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.
