AVex-73( Blarcamesine | AE-37 )

Catalog No. M21059 CAS No. 195615-83-9

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Product Name

AVex-73
Note

Research use only, not for human use.
Brief Description

AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
Description

AVex-73 is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
In Vitro

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In Vivo

Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration.Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice. Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response.Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice. Animal Model:Female Mecp2tm1.1Bird/J HET (C57 background) mice Dosage:10 mg/kg, 30 mg/kg Administration:Oral administration, daily, for 6.5 weeks Result:Reverse the deficits observed in the HET animals.
Synonyms

Blarcamesine | AE-37
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

muscarinic receptor
Research Area

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Indication

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1.Matsueda Gao S Efferson H et al. N-terminally LRMK-linked HER-2 peptides AE-37[J]. 2009.

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