APD597( APD597 | APD-597 | APD 597 | JNJ-38431055 )

Catalog No. M17648 CAS No. 897732-93-3

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HNMR

HPLC

MSDS

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Product Name

APD597
Note

Research use only, not for human use.
Brief Description

APD597 is a GPR119 agonist, used in the treatment of type 2 diabetes.
Description

APD597, also known as JNJ-38431055, is a potent and selective GPR119 agonist, which is potential useful for the treatment of type 2 diabetes. GPR119 agonists mediate a unique nutrient-dependent dual elevation of both insulin and glucagon like peptide 1/glucose-dependent insulinotropic peptide levels in vivo.
In Vitro

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In Vivo

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Synonyms

APD597 | APD-597 | APD 597 | JNJ-38431055
Pathway

Proteasome/Ubiquitin
Target

Serine Protease
Recptor

GPR119
Research Area

Metabolic Disease
Indication

——

CAS Number

897732-93-3
Formula Weight

479.55
Molecular Formula

C21H29N5O6S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 19 mg/mL; 39.62 mM
SMILES

Cc1c(ccc(n1)S(=O)(=O)C)Nc1c(c(ncn1)OC1CCN(CC1)C(=O)OC(C)C)OC
Chemical Name

isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate

1. Buzard DJ, et al. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-5.

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