Demethylwedelolactone

Research use only, not for human use.

Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.

Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice. DWEL derivatives exert anti-invasive growth effect on breast cancer cells.

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Proteasome/Ubiquitin

Serine Protease

trypsin

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6468-55-9

300.22

C15H8O7

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (333.09 mM)

O=C1C2=C(OC3=CC(O)=C(O)C=C32)C4=C(O)C=C(O)C=C4O1

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(-20℃)

With Ice Pack

≥ 2 years