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AKR1C3-IN-1

CAS No. 327092-81-9

AKR1C3-IN-1( —— )

Catalog No. M20737 CAS No. 327092-81-9

AKR1C3-IN-1 is a potent and selective inhibitor of AKR1C3(IC50 of 13 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AKR1C3-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    AKR1C3-IN-1 is a potent and selective inhibitor of AKR1C3(IC50 of 13 nM).
  • Description
    AKR1C3-IN-1 is a potent and selective inhibitor of AKR1C3(IC50 of 13 nM).
  • In Vitro
    AKR1C3-IN-1 shows less potent activities with 20.3±3.8 μM against AKR1C1 and >30 μM against AKR1C2 and AKR1C4. AKR1C3-IN-1 inhibits AKR1C3 activity (inhibiting PR-104H formation) with an IC50 of 0.027±0.002 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    AKR1C3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    327092-81-9
  • Formula Weight
    317.36
  • Molecular Formula
    C16H15NO4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (315.10 mM)
  • SMILES
    OC(=O)c1cccc(c1)S(=O)(=O)N1CCc2ccccc2C1
  • Chemical Name
    3-(34-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jamieson S M F Brooke D G Heinrich D et al. 3-(34-Dihydroisoquinolin-2(1 H )-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-β-Hydroxysteroid Dehydrogenase AKR1C3[J]. Journal of Medicinal Chemistry 2012 55(17):7746-7758.
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