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ABR-238901

CAS No. 1638200-22-2

ABR-238901( —— )

Catalog No. M35093 CAS No. 1638200-22-2

ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential as a compound for the treatment of myocardial infarction (MI).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ABR-238901
  • Note
    Research use only, not for human use.
  • Brief Description
    ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential as a compound for the treatment of myocardial infarction (MI).
  • Description
    ABR-238901 is an orally active and potent S100A8/A9 blocker and inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). ABR-238901 has the potential for myocardial infarction (MI) research.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL/KaLwRij mice with 5T33MMvv cells Dosage:30 mg/kg Administration:Gavage; daily; for 3 weeks Result:Caused less angiogenesis.Caused less IL6 and IL10 in myeloid-derived suppressor cells (MDSCs).
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    TLR
  • Recptor
    TLR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1638200-22-2
  • Formula Weight
    394.63
  • Molecular Formula
    C11H9BrClN3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (84.46 mM; Ultrasonic (<60°C); H2O : < 0.1 mg/mL (insoluble)
  • SMILES
    COc1ncc(cc1Br)S(=O)(=O)Nc1cncc(Cl)c1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kim De Veirman, et al. Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion. Cancer Immunol Res. 2017 Oct;5(10):839-846.?
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