2-D08
CAS No. 144707-18-6
2-D08( —— )
Catalog No. M20719 CAS No. 144707-18-6
2-D08 is a synthetic flavone that inhibits sumoylation also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 47 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 170 | In Stock |
|
| 50MG | 267 | In Stock |
|
| 100MG | 484 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name2-D08
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NoteResearch use only, not for human use.
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Brief Description2-D08 is a synthetic flavone that inhibits sumoylation also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
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Description2-D08 is a synthetic flavone that inhibits sumoylation also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetE1
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Recptorsumoylation|AXL
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Research Area——
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Indication——
Chemical Information
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CAS Number144707-18-6
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Formula Weight270.24
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Molecular FormulaC15H10O5
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Purity>98% (HPLC)
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SolubilityDMSO:150 mg/mL (555.06 mM)
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SMILESOc1ccc(-c2cc(=O)c3ccccc3o2)c(O)c1O
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Chemical Name2-(234-trihydroxyphenyl)-4H-1-benzopyran-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CC-92480
CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.CC-92480-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. It exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. CC-92480 is effective in CC-4047, CC-5013, and CC-220-resistant cell lines.
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M435-1279
M435-1279 is a UBE2T inhibitor that blocks UBE2T-mediated degradation of RACK1, thereby inhibiting the hyperactivation of the Wnt/β-catenin signaling pathway.
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TAK-243
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1).
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