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Home - Products - Cell Cycle/DNA Damage - c-Myc - 10074-A4

10074-A4

CAS No. 312631-87-1

10074-A4( —— )

Catalog No. M28813 CAS No. 312631-87-1

10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features from that of a non-binding ligand.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    10074-A4
  • Note
    Research use only, not for human use.
  • Brief Description
    10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features from that of a non-binding ligand.
  • Description
    10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features from that of a non-binding ligand.(In Vitro):10074-A4 showed binding affinity with c-Myc370–409 with Kd of 36.3?±?9.0?μM and EC50 of 15.1?±?2.3?μM.10074-A4 arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells.
  • In Vitro
    10074-A4 shows inhibitory activity of HL-60 cells with an IC50 of 15.1?μM.10074-A4 (25-50 μM; 24 hours) arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells. 10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4.10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain and its binding behavior could be described as a ‘ligand cloud’. Even in the bound state, the structure of the c-Myc370-409 peptide remained a dynamic ensemble. The 10074-A4 ligand bound at different sites throughout the c-Myc370-409 chain with different strength. Cell Viability Assay Cell Line:HL-60 cells Concentration:25 μM, 50 μM Incubation Time:24 hours Result:Arrested the cell cycle at the S-phase.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    c-Myc
  • Recptor
    Ferroptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    312631-87-1
  • Formula Weight
    409.28
  • Molecular Formula
    C18H14Cl2N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (305.41 mM)
  • SMILES
    OC(CN1C(=O)CSC1=O)Cn1c2ccc(Cl)cc2c2cc(Cl)ccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gaschler MM, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515.
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